Composition for preventing improving or treating disorder associated with androgen receptor comprising extract of Lithospermi Radix as effective component
KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION;KOREA INSTITUTE OF ORIENTAL MEDICINE
发明人:
SHIN, HYEUN KYOO,신현규,HA, HYE KYUNG,하혜경,LEE, MEE YOUNG,이미영,SEO, CHANG SEOB,서창섭,DONG, MI SOOK,동미숙,SUN, SEOUNG HAN,선승한
申请号：
KR1020170049238
公开号：
KR1018762010000B1
申请日:
2017.04.17
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention relates to a composition for preventing, ameliorating, or treating androgen receptor (AR)-related disease containing a lithospermum extract as an active ingredient. The lithospermum extract used as the active ingredient of the present invention has anti-androgen activities, and inhibits binding of dihydrotestosterone (DHT) to AR, thereby being effectively used for preventing, ameliorating, or treating at least one receptor-related disease selected among prostate cancer, dysuria, androgen-dependent hair loss, and prostate hypertrophy.본 발명은 자근 추출물을 유효성분으로 포함하는 안드로겐 수용체 관련 질환의 예방, 개선 또는 치료용 조성물에 관한 것으로, 본 발명의 유효성분인 자근 추출물은 항안드로겐 활성이 있으며, DHT(Dihydrotestosterone)의 AR 결합을 억제하는 효과가 있으므로, 안드로겐 수용체 관련 질환인 전립선비대증, 안드로겐 의존성 탈모, 배뇨장애 및 전립선암 중에서 선택된 하나 이상의 질환 예방, 개선 또는 치료에 효과적으로 사용될 수 있다.
