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Improved antigen alliance receptor
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
KLEIN, Christian,STUBENRAUCH, Kay-Gunnar,MOESSNER, Ekkehard,DAROWSKI, Diana
申请号:
PE2019001946
公开号:
PE20200152A1
申请日:
2018.03.26
申请国别(地区):
PE
年份:
2020
代理人:
摘要:
The invention refers to an antimatter alliance receiver, which includes a super membrane anchoring domain and an outer domain, including a part of antimatter alliance, In this case, the part polymerized to Antonio can be bound to a specific crystal block domain mutation, but not to a specific mutation free parent domain, in which the mutation parent domain contains at least one alternative amino acid compared with the mutation free parent domain. In addition, the invention refers to a kit containing the invented T cell and / or nucleic acid molecule,The vehicle represents a receiver that binds to the antibodies of the invention and one or more tumor target antibodies, including a mutated Fc domain. The invention also provides a method for producing and using T cells as a treatment for specific diseases, as well as specific tumor antibodies, and drug synthesis and drugs including T cells and / or therapeutic antibodies, In this case, the cell t must be combined with one or more antibodies, with the target oncologist, including a mutated FC fieldLa presente invencion se refiere a un receptor de union a antigeno que comprende un dominio transmembranal de anclaje y un dominio extracelular que comprende una fraccion de union a antigeno, en el que la fraccion de union a antigeno es capaz de union especifica a un dominio de fragmento cristalizable (Fc) mutado pero no es capaz de union especifica al dominio Fc parental no mutado, en el que dominio Fc mutado comprende por lo menos una sustitucion de aminoacidos en comparacion con el dominio Fc parental no mutado. Ademas, la invencion se refiere a un kit que comprende las celulas T de la invencion y/o moleculas de acidos nucleicos, vectores que expresan receptores de union a antigeno de la presente invencion y uno o mas anticuerpos con diana tumoral que comprenden un dominio Fc mutado. La invencion proporciona ademas la produccion y utilizacion de celulas T en un metodo para el tratamiento de enfermedades particulares junto c
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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