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マイクロニードルアレイの製造方法
专利权人:
FUJIFILM CORPORATION
发明人:
KABATA Koki,下野浩貴,WAKAMATSU Satoshi,若松哲史
申请号:
JPJP2017/014962
公开号:
WO2017/179613A1
申请日:
2017.04.12
申请国别(地区):
WO
年份:
2017
代理人:
摘要:
The present invention addresses the problem of providing a method for manufacturing a microneedle array such that shape change of needle portions are suppressed in high humidity environments. The present invention provides the method for manufacturing a microneedle array that includes: a filling step of filling needle-shaped recesses of a mold having the needle-shaped recesses with an aqueous solution in which a first water-soluble polymer is dissolved a drying and solidifying step of drying the aqueous solution in which the first water-soluble polymer is dissolved and with which the needle-shaped recesses are filled a supplying step of supplying an aqueous solution in which a second water-soluble polymer is dissolved to the needle-shaped recesses in which the first water-soluble polymer is dried and solidified and a polymer layer forming drying step of drying the aqueous solution in which the second water-soluble polymer that was supplied to the mold is dissolved to form a polymer layer. In the microneedle array, the first water-soluble polymer is a water-soluble polymer that easily dissolves in water at 25°C at a concentration of 10% by mass, and the second water-soluble polymer has an equilibrium moisture content that is 1.1 times higher than the equilibrium moisture content of the first water-soluble polymer, the equilibrium moisture content of the second water-soluble polymer being 25% or less.La présente invention vise à fournir un procédé de fabrication dun ensemble de micro-aiguilles de telle sorte que le changement de forme des parties daiguille est supprimé dans des environnements à humidité élevée. La présente invention décrit le procédé de fabrication dun ensemble de micro-aiguilles qui comprend : une étape de remplissage consistant à remplir des évidements en forme daiguilles dun moule ayant les évidements en forme daiguilles avec une solution aqueuse dans laquelle un premier polymère soluble dans leau est dissous une étape de séchage et de solidificati
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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