您的位置: 首页 > 农业专利 > 详情页

COMPOUNDS FOR TREATMENT OF TUMORS BEARING DEREGULATED MYC ONCOPROTEINS
专利权人:
QUATTRONE; Alessandro
发明人:
QUATTRONE, Alessandro,SIDAROVICH, Viktoryia,ADAMI, Valentina
申请号:
IBIB2011/052735
公开号:
WO2011/161631A3
申请日:
2011.06.22
申请国别(地区):
WO
年份:
2012
代理人:
摘要:
Compound of Formula (I): wherein R1, R2 and R3, which are identical or different, are hydrogen atom or C1-4 alkyl, and R4 is a saturated C6-9 linear, branched or cyclic hydrocarbon radical or a radical of Formula (II) wherein X is S or O, Y is a hydrogen atom or up to 2 halogen atoms, Z is a single bond or a divalent radical being O, S, - CR2-, in which R is hydrogen or C1-4 alkyl, or other divalent radical with 2-10 carbon atoms and, optionally, O and/or S atoms linked in the form of a chain, wherein - if the radicals contain 2 or more O and/or S atoms - the latter are separated from one another by at least 2 carbon atoms, and it also being possible for 2 adjacent carbon atoms to be linked together by a double bond, and the free valencies of the carbon atoms being saturated by a hydrogen atom and/or C1-4 alkyl groups, Ar is an aromatic ring system which has up to two rings and which may be substituted by up to three radicals from the group of fluorine, chlorine, bromine, methoxy, C1-4 alkyl, trifluoromethyl and trifluoromethoxy, salts and/or solvates thereof, for use in the treatment of a tumor bearing deregulated MYC oncoproteins, wherein said compound is capable of increasing UTR-dependent expression of at least one MYC gene.Composé de Formule (I), ainsi que ses sels et solvates, destinés à être utilisés pour traiter une tumeur portant des oncoprotéines MYC dérégulées, ledit composé étant capable daugmenter lexpression dépendante dUTR dau moins un gène MYC. Dans la Formule (I), R1, R2 et R3, qui peuvent être identiques ou différents, sont un atome dhydrogène ou un alkyle C1-4, et R4 est un radical hydrocarbure C6-9 saturé, linéaire, ramifié ou cyclique ou un radical de Formule (II) où X est S ou O, Y est un atome dhydrogène ou jusquà 2 atomes dhalogène, Z est une liaison simple ou un radical divalent de type O, S, - CR2-, R étant un atome dhydrogène ou un alkyle C1-4, ou un autre radical divalent ayant de 2 à 10 atomes de carbone et, éventuellement, des atomes O
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充