The present invention is directed to an ophthalmic composition comprising semifluorinated compounds characterized by the general formula CF3-[CF2]n-CH[CH3]-[CH2)m-CH3 wherein n is an integer selected from 3 to 5 and m is an integer selected from 1 to 5. The invention further provides the use of the composition as medicament for topical administration to the eye, as well as a kit comprising the composition and a container comprising a dispensing means such as a dropper.