JUNE CARL H.,LEVINE BRUCE L.,PORTER DAVID L.,KALOS MICHAEL D.,MILONE MICHAEL C.
申请号：
NZ61251211
公开号：
NZ612512A
申请日:
2011.12.09
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is an isolated nucleic acid sequence encoding a chimeric antigen receptor (CAR), wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the CD3 zeta signaling domain comprises the amino acid sequence of SEQ ID NO: 24； wherein the sequence is as disclosed in the specification.
