KIM DAE JIN,LEE BYUNG SUN,HONG SUNG HWAN,HUH YONG HO,JUNG SUNG YOUB,KWON SE CHANG
申请号：
IN3559/DELNP/2014
公开号：
IN2014DN03559A
申请日:
2014.05.02
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The present invention relates to a blood coagulation factor VII derivative, a blood coagulation factor Vila derivative, FacVII and FacVlla conjugates each prepared by linking a polymer capable of extending the blood half-life to the derivative, FacVII and Vila complexes each prepared by linking a carrier to the conjugate, genes encoding the FacVII and FacVlla derivatives, expression vectors comprising the genes, transformants introduced with the expression vectors, a method for preparing the FacVII and FacVlla derivatives using the transformants, a method for preparing the FacVlla conjugate and complex, a FacVlla complex prepared by the method, a pharmaceutical composition for the prevention or treatment of hemophilia comprising the derivative, conjugate, or complex as an active ingredient, and a pharmaceutical composition for blood coagulation comprising the derivative, conjugate, or complex as an active ingredient. Further, the present invention relates to a method for preventing or treating hemophilia or for promoting blood coagulation, comprising administering to a subject a therapeutically effective amount of the composition. The FacVII or FacVlla derivative of the present invention is able to bind with a carrier capable of improving the blood half-life while maintaining the activity of FacVII or FacVlla, and they can be widely used in the development of effective prophylactic or therapeutic agent for hemophilia.
