Mineral Coated Microparticles for Co-Delivery of Anti-Inflammatory Molecules with Nucleic Acids to Improve Gene Delivery Outcomes

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专利权人:

Wisconsin Alumni Research Foundation

发明人:

William L. Murphy,Andrew Salim Khalil,Xiaohua Yu

申请号：

US16626973

公开号：

US20200170958A1

申请日:

2018.07.05

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Disclosed are compositions and methods for the co-delivery of ribonucleic acids and interferon binding proteins. Compositions include mineral coated microparticles having a mineral layer, a ribonucleic acid, and an interferon binding protein. Ribonucleic acids and interferon binding proteins can be adsorbed to the mineral layer, can be incorporated into the mineral layer, and combinations thereof. Also disclosed are methods for co-delivery of ribonucleic acids and interferon binding proteins and methods for treating inflammatory diseases using mineral coated microparticles having a mineral layer to provide co-delivery of ribonucleic acids and interferon binding proteins.

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中国工程科技知识中心

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