BIRUDARAJ, KONDAMRAJ,BRANDL, MICHAEL THOMAS,HEGDE, SHRIDAR,SANA, FELIX,STEFANIDIS, DIMITRIOS
申请号：
AT08717935
公开号：
AT540672T
申请日:
2008.03.18
申请国别(地区):
AT
年份:
2012
代理人:
摘要：
The present invention relates to a method of forming granules of (2R,3S,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-azido-3,4-bis-iso-butyryloxy-tetrahydro-furan-2-ylmethyl isobutyrate； hydrochloride salt (I), comprising mixing I, with a granulating amount of a granulating liquid, and a polyethylene glycol (PEG)/polypropylene glycol (PPG) block copolymer as a binder and solubility enhancer to form wet granules which are then dried to remove the granulating liquid.
