MÉTHODE DE DIFFÉRENCIATION DE CELLULES CARTILAGINEUSES, DE CELLULES OSSEUSES, DE CELLULES NERVEUSES OU D'ADIPOCYTES À PARTIR DE CELLULES STROMALES MÉSENCHYMATEUSES HUMAINES DU CORNET INFÉRIEUR
CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION;가톨릭대학교 산학협력단;김성원;KIM, Sung Won
发明人:
KIM, Sung Won,김성원
申请号：
KRKR2011/001947
公开号：
WO2011/118954A3
申请日:
2011.03.22
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
The present invention relates to a method for inducing differentiation of human inferior turbinate mesenchymal stromal cells to bone cells, cartilage cells or nerve cells. More particularly, the present invention relates to a method for inducing differentiation of human inferior turbinate mesenchymal stromal cells to bone cells, cartilage cells, nerve cells or fat cells, wherein the method comprises the step of culturing the mesenchymal stromal cells that are isolated from human inferior turbinate tissues in a medium containing growth factors. The present invention also relates to a composition for prevention or treatment of cartilage injury or disease, bone injury or osseous metabolic disease, or nerve injury or disease that contain cells differentiated by said method as active ingredients. The bone cells, cartilage cells, nerve cells or fat cells differentiated from human inferior turbinate mesenchymal stromal cells according to the present invention can be used in the fields of cell replacement therapy and regenerative medicine for treating diseases caused by the damage of said cells, and the human inferior turbinate tissues used in the present invention can be easily obtained as the source of the cells from the discarded tissues during inferior turbinate surgery.La présente invention a pour objet une méthode permettant d'induire la différenciation de cellules stromales mésenchymateuses humaines du cornet inférieur en cellules osseuses, en cellules cartilagineuses ou en cellules nerveuses. Plus particulièrement, la présente invention concerne une méthode permettant d'induire la différenciation de cellules stromales mésenchymateuses humaines du cornet inférieur en cellules osseuses, en cellules cartilagineuses, en cellules nerveuses ou en adipocytes, la méthode comprenant l'étape consistant à cultiver les cellules stromales mésenchymateuses qui sont isolées à partir de tissus humains du cornet inférieur dans un milieu contenant des facteurs de croissance. La prése
