Systems and methods are provided for quantifying and providing indicia of ST-segment resolution in an electrocardiogram (ECG) signal. A receiver acquires an electrocardiogram (ECG) signal that includes an ST-segment. A processor processes the ECG signal to determine values for the ST-segment deviation relative to an isoelectric baseline. A user is allowed to provide a baseline signal to the processor. The processor responds to the baseline signal by marking a baseline ST-segment value corresponding to a baseline time. A user interface displays a linear graphical trend of variations in the measured ST-segment values relative to the baseline ST-segment value. In certain embodiments, the processor detects user-selected trigger events such as post-intervention ST deviation relative to the baseline time and the baseline ST-segment value, and provides indicia of the trigger event. In addition, or in other embodiments, a verbal annunciation of a percent ST-segment resolution is provided.
