Edward Norbert Van Den Brink;Cornelis Adriaan De Kruif;Mark Throsby
发明人:
Edward Norbert Van Den Brink,Cornelis Adriaan De Kruif,Mark Throsby
申请号：
US13458964
公开号：
US20120276115A1
申请日:
2012.04.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Described are binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. Also described are nucleic acid molecules encoding the antibodies, and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis, and/or treatment of an influenza virus H5N1 infection. In certain embodiments, the antibodies provide cross-subtype protection in vivo, such that infections with H5, H2, H6, H9, and H1-based influenza subtypes can be prevented and/or treated.
