JANSSEN VACCINES & PREVENTION B.V.;EDWARD NORBERT VAN DEN BRINK;CORNELIS ADRIAAN DE KRUIF;MARK THROSBY
发明人:
MARK THROSBY,CORNELIS ADRIAAN DE KRUIF,EDWARD NORBERT VAN DEN BRINK
申请号：
IL24929116
公开号：
IL249291A
申请日:
2016.11.29
申请国别(地区):
IL
年份:
2018
代理人:
摘要：
The present invention relates to binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. The disclosure provides nucleic acid molecules encoding the antibodies, their sequences and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H5N1 infection. In a preferred embodiment, the antibodies provide cross-subtype protection in vivo , such that infections with H5, H2, H6, H9 and H1-based influenza subtypes can be prevented and/or treated.
