Van Den Brink, Edward Norbert,De Kruif, Cornelis Adriaan,Throsby, Mark
申请号：
AU2012216734
公开号：
AU2012216734B2
申请日:
2012.09.07
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
#$%^&*AU2012216734B220150305.pdf#####C. NRPfnb DCC SCG44498156_I DOC-2717/2012 ABSTRACT The present invention relates to binding molecules such as human monoclonal antibodies that bind to influenza virus H5N I and have neutralizing activity against influenza virus H5N 1. The disclosure provides nucleic acid molecules encoding the antibodies, their sequences and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H5NI infection. In a preferred embodiment, the antibodies provide crosssubtype protection in vivo, such that infections with H5, H2, H6, H9 and HI-based influenza subtypes can be prevented and/or treated.
