De Kruif, Cornelis Adriaan,Van Den Brink, Edward Norbert,Throsby, Mark
申请号：
AU2007293662
公开号：
AU2007293662B2
申请日:
2007.09.06
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention relates to binding molecules such as human monoclonalantibodies that bind to influenza virus H5N1 and have neutralizing activityagainst influenza virus H5N1. The disclosure provides nucleic acid moleculesencoding the antibodies, their sequences and compositions comprising the antibodiesand methods of identifying or producing the ant ibodies. The antibodies can beused in the diagnosis, prophylaxis and/or treatment of an influenza virus H5N1infection. In a preferred embodiment, the antibodies provide cross- subt ypeprotection in vivo, such that infections with H5, H2, H6, H9 and H1-based influenzasubtypes can be prevented and/or treated.
