Fused aminodihydrothiazine derivatives useful as BACE inhibitors

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专利权人:

Ltd.;Eisai R&D Management Co.

发明人:

Hall, Adrian,Farthing, Christopher Neil,Castro Pineiro, Jose Luis

申请号：

AU2012208526

公开号：

AU2012208526B2

申请日:

2012.01.20

申请国别(地区):

AU

年份:

2015

代理人:

摘要：

The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein X is hydrogen or fluorine； A is CH or N； Y is methyl, ethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, difluoroethyl, methoxy, ethoxy, methoxymethyl or -C≡N； and pharmaceutically acceptable salts thereof； which compound has an Αβ production inhibitory effect or a BACEl inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Αβ and typified by Alzheimer-type dementia.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/