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PROCÉDÉS ET COMPOSITIONS POUR MODIFIER L'ADN GÉNOMIQUE
专利权人:
Maxcyte; Inc.
发明人:
申请号:
EP17830593.4
公开号:
EP3487992A4
申请日:
2017.07.21
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
Compositions and methods concern the sequence modification of an endogenous genomic DNA region. Certain aspects relate to a method for site-specific sequence modification of a target genomic DNA region in cells comprising: transfecting the cells by electroporation with a composition comprising (a) a DNA oligo; (b) a DNA digesting agent; and (c) a targeting RNA, wherein the targeting RNA is capped and/or polyadenylated; wherein the donor DNA comprises: (i) a homologous region comprising nucleic acid sequence homologous to the target genomic DNA region and (ii) a sequence modification region; and wherein the genomic DNA sequence is modified specifically at the target genomic DNA region.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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