Leonard H. Rome, Ph.D.,Daniel Buehler,Heather D. Maynard
申请号：
US15027467
公开号：
US20160235862A1
申请日:
2014.10.17
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention relates to compositions of vault complexes for use as delivery agents for hydrophobic and/or aqueous insoluble therapeutic compounds. In one aspect, provided herein is a vault complex comprising a modified major vault protein (MVP), wherein the modified major vault protein comprises a fusion peptide, wherein said fusion peptide is fused to the N-terminus of the major vault protein, and wherein said peptide provides enhanced sequestering of a hydrophobic and/or aqueous insoluble therapeutic compound within the vault complex.
