ROSS RONALD,DEAMICIS CARL,ZHU YUANMING,NIYAZ NOORMOHAMED M,WEST SCOTT P,ROTH GARY,ARNDT KIM E
申请号：
IN9837/DELNP/2014
公开号：
IN2014DN09837A
申请日:
2014.11.20
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The invention disclosed in this document is related to the field of processes to produce certain 2- (pyridine- 3 -yl)thiazoles as intermediates for the synthesis of pesticidal thiazole amides. Compounds (I) and (lla) are reacted to produce compound (lib). Compounds (Ua) and (lib) can be in the form of a salt or free base. The reaction is conducted in the presence of a base such as tnethylamine, when compound (Ua) is a salt, and the reaction is conducted in a polar protic solvent. Compounds (lib) and (llc) are reacted to produce compound (III) , in a polar solvent such as an ether or an alcohol. Compound (III) is cyclized using a dehydrating agent. Examples of such dehydrating agents include, but are not limited to POCI3, H2S04, SOCI2, P205 , polyphosphoric acid , p - toluene sulfonic acid, and trifluoroacetic anhydride.
