Disclosed herein is a solid oral gastroretentive dosage form of paracetamol comprising a system of hydrophilic swellable floating matrix in combination with a bioadhesive system, wherein said combination of drug delivery system consists of hydrogel(s), superdisintegrant(s), microenvironmental pH modifier(s) and pharmaceutically acceptable excipients. The gastroretentive drug delivery system of present invention provides enhanced bioavailability, reduced side effects, stable formulation and offers better patient compliance by reducing dosing frequency and adverse drug reactions.
