#$%^&*AU2012202743B220140227.pdf#####Abstract The invention relates to a multiparticulate modified release composition that in operation delivers an active ingredient in a pulsed or bimodal manner. The 5 multiparticulate modified release composition comprises an immediate release component and a modified release component； the immediate release component comprising a first population of active ingredient containing particles and the modified release component comprising a second population of active ingredient containing particles coated with a controlled release coating； wherein the combination of the 10 immediate release and modified release components in operation deliver the active ingredient in a pulsed or a bimodal manner. The invention also relates to a solid oral dosage form containing such a multiparticulate modified release composition. The plasma profile achieved by the multiparticulate modified release composition is advantageous in reducing a patient tolerance to the active ingredient and in increasing 15 patient compliance by reducing dosage frequency.
