A method is provided for preventing leakage of blood from a vessel. The method includes inserting a portion of an apparatus into a puncture tract extending through tissue to a puncture in the vessel the apparatus including a thrombogenic matrix disposed in a distal portion of the apparatus. The method also includes deploying the thrombogenic matrix from the distal portion of the apparatus and into the puncture tract, the thrombogenic matrix being exposed to blood and compressively engaging the tissue surrounding the vessel to prevent leakage of blood.
