The present invention relates to the use of iodinated activated charcoal, optionally in combination with a bromide salt, in treatment of one or more symptom(s) caused by depression, wherein said symptom(s) is/are selected from the group consisting depressive mood, emotional fatigue, mental fatigue which can be chronic, burnout, withdrawal from social situations, anxiety, concentration problems, unpleasant heart palpitations, irregular heart beats, a feeling of pressure in the chest, irritable bowel syndrome and sexual dysfunction.