Disclosed is a compound having the formula (I) e.g. 4-(4-chloro-phenyl)-3-(4-methyl-benzenesulfonyl)-quinoline wherein the substituents are defined in the specification and/or salts and/or hydrates and/or solvates thereof for the treatment and/or prevention of a disease selected from psychiatric disorders, neurological disorders, chronic and acute pain, neuromuscular dysfunctions of the lower urinary tract, gastrointestinal reflux disease, irritable bowel syndrome, substance abuse and withdrawal.