Provided is a mammalian tooth-shaped scaffold including a composition that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic. Also provided is a method of replacing a tooth in the mouth of a mammal, where the tooth is absent and a tooth socket is present in the mouth at the position of the absent tooth. The method comprises implanting a scaffold having the shape of the missing tooth into the tooth socket. Additionally, a method of making a tooth scaffold is provided. The method comprises synthesizing a scaffold in the shape of a mammalian tooth and adding at least one composition that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic.
