Claim 1: a method for the treatment, improvement or prevention of metabolic diseases； the method includes providing a formula compound (1) or an effective treatment amount of an acceptable salt on a matched isomer, acoustic isomer, solution or drug to a person in need； Among them, he is an alien Ariel selected from this group, which is composed of tienilo, furanilla, tiazolilo, isotiazolilo, oxazolilo, pirideni, isoxazolilo, imidazzolilo, furazan-3-il, pirazolilo, triazolilo, tetrazolilo and [1.2.3] sulfur and phosphorus； it can be replaced and replaced independently, 1 to 2 alternatives selected from the fluorine, chlorine and bromine groups,1. Lease of c83218331 and 83242431；cyano, and trifluoromethyl； Z is a heteroaryl selected from the group consisting of indolyl, indazolyl, benzoxazolyl, benzothiazolyl, benzothienyl, benzofuranyl, imidazo [1,2-a] pyridin-2-yl, pyrrolo [2,3-b] pyridinyl, pyrrolo [3, 2-b] pyridinyl, thieno [2,3-b] pyridinyl, quinolinyl, quinazolinyl, and benzimidazolyl； wherein said Z is optionally substituted independently with one to two substituents selected from the group consisting of C₁₋₄ alkyl,1. Trifluoroid, 2, 2, 2-trifluoroid Xi methyl, 2, 2, 2, 2-trifluoroid, trifluoroid, chlorine, fluorine, bromine, iodine； provided that a formula compound (1) is different from a compound in which endosulfan-4-ilo and Z are 5-fluoro-3h-benzodiazepine-2-ilo； a compound in which endosulfan-2 (a) 1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,Or a compound in which y is thiazole-2-ilo and Z is 6-trifluoromethyl-pyridine [1,2-a] pyridine-2-ilo. Claim 9: a method for treating, improving or preventing metabolic diseases； the method includes providing effective 1 - (1 - [3-chloro-6 - (trifluoride) - 1-benzotiofen-2-il) carbides, azetidin-3-il-4 - (1,3-thiazol-4-icarboni) formula (2) pyridine to the subject needing treatment.Or a delicious or medically acceptable salt Claim 12: use of formula compound (2) as part of claim 9 for the production of dr
