The invention relates the method, apparatus, and system of the correction of energy crosstalk in dual-isotope simultaneous acquisition (DISA), the system includes a collimator, a metal thin film, a detecting unit, an analyzing unit and a display unit for analyzing a energy distribution chart of dual isotopes, and use the specific equation or artificial neural network method or independent component analysis to compare the energy distribution which is with and without metal thin film. The invention uses the metal thin film to remove the energy contamination for simultaneous acquisition of two isotopes whose photopeak energies are close, the invention effectively separate the two isotopes which are reconstructed to generate image without crosstalk, therefore, improves image quality and relieves patient’s discomfort.本發明關於一種雙同位素同時攫取的能量交疊修正的方法、裝置以及系統,包括準直器、金屬薄膜、偵測單元、分析單元以及顯示單元,用以分析雙同位素的能量分佈圖,利用特定方程式或類神經網路方式或獨立分析成分分析方式來比較有或無貼附金屬薄膜所得之能量分佈圖。本發明使用金屬薄膜來去除雙同位素中能量交疊的範圍,並還原出無能量交疊的原始圖形,因此,能有效提高影像品質以及降低病人的不適感。301‧‧‧檢測器303‧‧‧準直器305‧‧‧金屬薄膜307‧‧‧雙同位素