JIN, HONG,TANG, RODERICK,LI, SHENGQIANG,BRYANT, MARTIN
申请号：
CA2430115
公开号：
CA2430115C
申请日:
2001.11.28
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention relates to genetically engineered recombinantrespiratory syncytial viruses and viral vectors which contain deletions ofvarious viral accessory gene(s) either singly or in combination. In accordancewith the present invention, the recombinant respiratory syncytial viralvectors and viruses are engineered to contain complete deletions of the M2-2,NS1, NS2, or SH viral accessory genes or various combinations thereof. Inaddition, the present invention relates to teh attenuation of respiratorysyncytial virus by mutagenisis of the M2-1 gene.
