RUAT, Martial,FAURE, Hélène,GOROJANKINA, Tatiana,MANN, André,TADDEI, Maurizio,MANETTI, Fabrizio,SOLINAS, Antonio
申请号：
ES11794858
公开号：
ES2651015T3
申请日:
2011.11.15
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Compounds of general formula (I): ** Formula ** in which: - X, in ortho, meta or para position, represents -H, -OH, -NH2, a halogen atom, an alkyl radical consisting of a carbon chain of 1 to 10 carbon atoms, linear or branched, an alkoxy radical, a cycloalkyl of 3 to 8 carbon atoms or an aryl group； - R8, in ortho, meta or para position, on a carbon different from that carried by the radical X, represents: - (C>； = O) - NH-R1, - (C>； = O) -O-R1 or NH- (C>； = O) -R1； - W represents -H, -OH, -NH2 or a halogen atom, - R1, R2 and R3 identical or different and independently of each other, represent: - a hydrogen atom； or - an alkyl group consisting of a carbon chain of 1 to 10 carbon atoms, linear or branched, optionally unsaturated by one or more double or triple bonds, optionally substituted with one or more heteroatoms, with one or more halogen atoms or with one or several aryl or heteroaryl groups； or - a cycloalkyl of 3 to 8 carbon atoms optionally substituted with a radical consisting of a carbon chain of 1 to 10 carbon atoms, linear or branched, or with an alkoxy radical； - R4, R5, R6 and R7 identical or different and independently of each other, are selected from -H, -Cl, -Br, -I, -CN, -NO2, an alkyl radical consisting of a carbon chain of 1 to 10 carbon atoms, linear or branched, an alkoxy radical or a cycloalkyl of 3 to 8 carbon atoms； it being understood that R3 and R4 can be fused to form, with the carbon atoms and the adjacent nitrogen of the quinoline cycle that carries them, a 5 to 6 member cycle； for its use for the treatment of diseases caused by the derangement of the function or differentiation of osteoblasts and / or by the functional imbalance between osteoblasts and osteoclasts, allowing such use to induce cell differentiation of stem or progenitor cells.Compuestos de fórmula general (I):**Fórmula** en la cual: - X, en posición orto, meta o para, representa -H, -OH, -NH2, un átomo de halógeno, un radical alquilo que consiste en una cadena car
