As for this invention, multiplication of the lymphatic vessel endotherium and/or being something regarding the method of obstructing wandering and the method of obstructing the lymphatic vessel new life in the object, as for the aforementioned method, in the object or in the lymphatic vessel endotherium which is derived from the aforementioned object, the collagen type IV origin characteristic NC1 domain polypeptide or the effective quantity of fragment, the effective quantity of these derivatives or the mutant, these the cord/code the fact that the effective quantity of the medicine which can increase the effective quantity of the polynucleotide which is done, or the revelation or production of the NC1 domain polypeptide is prescribed is included. Also the method where it remedies or prevents the disease and the sick condition which accompany abnormal lymphatic vessel endotherium activity is offered.本発明は、対象においてリンパ管内皮細胞の増殖及び/又は遊走を阻害する方法及びリンパ管新生を阻害する方法に関するものであって、前記方法は、対象に又は前記対象に由来するリンパ管内皮細胞に、コラーゲンタイプIV由来性NC1ドメインポリペプチド又は断片の有効量、これらの誘導体又は変異体の有効量、これらをコードするポリヌクレオチドの有効量、あるいはNC1ドメインポリペプチドの発現又は産生を増加させることができる薬剤の有効量を投与することを含む。異常なリンパ管内皮細胞活性に伴う疾患及び病態を治療又は予防する方法も提供される。
