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ИММУНОМОДУЛИРУЮЩИЕ КОМПОЗИЦИИ, СПОСОБЫ И СИСТЕМЫ, СОДЕРЖАЩИЕ ИММУНОГЕННЫЕ ФРАГМЕНТЫ АроВ100
专利权人:
СЕДАРС-СИНАИ МЕДИКАЛ СЕНТЕР (US)
发明人:
ШАХ Предиман К. (US),ЧИУ Куанг-Иух (US)
申请号:
RU2013126888/10
公开号:
RU2013126888A
申请日:
2011.11.11
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method for the treatment and / or prophylaxis of a condition whose treatment is carried out using an immunogenic fragment of ApoB-100, or an immunogenically active part, in a human, the method vklyuchaetvvedenie individual an effective amount of at least one immunogenic fragment of ApoB-100, or an immunogenically active part, wherein the immunogenic fragment comprises one of SEQ ID NO: 1-302, and wherein the effective amount is less than 1 mg.2. The method of claim 1, wherein the immunogenic fragment is linked to the decrease ateroskleroza.3. The method of claim 1, wherein the immunogenic fragment comprises one or more immunogenic fragments or their immunogenically active chastey.4. A method according to any one of claims 1-3, wherein one or more immunogenic fragments contain one or more peptides, each of which contains one of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 11, SEQ ID NO: 25, SEQ ID NO: 45, SEQ ID NO: 74, SEQ ID NO: 99, SEQ ID NO: 100, SEQ ID NO: 102, SEQ ID NO: 103, SEQ ID NO: 105, SEQ ID NO: 129, SEQ ID NO: 143, SEQ ID NO: 148, SEQ ID NO: 210 or SEQ ID NO: 301.5. A method according to any one of claims 1-3, wherein one or more immunogenic fragments contain one or more peptides, each of which contains one of SEQ ID NO: 2, SEQ ID NO: 11, SEQ ID NO: 45, SEQ ID NO: 74, SEQ ID NO: 102, SEQ ID NO: 148, SEQ ID NO: 162 or SEQ ID NO: 210.6. A method according to any one of claims 1-3, wherein one or more immunogenic fragments comprise a peptide having SEQ ID NO: 143 and peptide having SEQ ID NO: 210.7. A method according to any one of claims 1-3, wherein one or more immunogenic fragments comprise a peptide having SEQ ID NO: 11, the peptide having SEQ ID NO: 25 and peptide having SEQ ID NO: 74.8. A method according to any one of claims 1-3, wherein one or more immunogenic fragments comprise a peptide having SEQ ID NO: 2.9. A method according to any one of claims 1-3, wherein one or more immunogenic fragments comprise a peptide having SEQ ID NO: 45.10. way of1.
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