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Production of fertile XY animals from XY ES cells
专利权人:
David Valenzuela;Wojtek Auerbach;Thomas Dechiara;David Frendewey;William Poueymirou
发明人:
Wojtek Auerbach,Thomas Dechiara,William Poueymirou,David Frendewey,David Valenzuela
申请号:
US13157728
公开号:
US09149026B2
申请日:
2011.06.10
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Methods and compositions are described for making phenotypically female fertile animals from XY donor cells and suitable host embryos. Culture media and methods are provided for maintaining XY donor cells in culture that after introduction into a host embryo and gestation in a suitable host will result in fertile XY female animals. Methods and compositions are described for making fertile female animals in an F0 generation from a donor XY cell and a host embryo, as are methods for making F1 progeny that are homozygous for a modification from a heterozygous F0 fertile male and a heterozygous F0 fertile female sibling.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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