NG STEVEN Y,NG, STEVEN Y.,SHEN HUI-RONG,SHEN, HUI-RONG,HELLER JORGE,HELLER, JORGE
申请号：
ES05802951
公开号：
ES2529574T3
申请日:
2005.09.27
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A pharmaceutical composition comprising: (A) a semisolid vehicle administration comprising: (i) a polyorthoester of formula I or formula II ** ** Formula where: R is a bond, - (CH2) a- or - (CH2) bO- (CH2) c- wherein a is an integer between 1 and 10, and b and c are independently integers between 1 and 5 R * is a C1-4 alkyl n is an integer of at least 5 and A is R1, R2, R3 or R4, where R1 is: ** ** Formula where: p is an integer between 1 and 20 R5 is hydrogen or C1-4 alkyl and R6 is: ** ** Formula where: s is an integer from 0 to 30 t is an integer between 2 and 200 and R7 is hydrogen or C1-4 alkyl R2 is: R3 ** ** Formula is: ** ** Formula where: x is an integer between 0 and 30 y is an integer between 2 and 200 R8 is hydrogen or C1-4 alkyl R9 and R10 are independently C1-12 alkylene R11 is hydrogen or C1-6 alkyl and R12 is C1-6 alkyl or R11 and R12 together are C3-10 alkylene and R4 is the residue of a diol containing at least one functional group independently selected from urethane amide, imide, urea, and in at least 0.01 mole percent of the A units they are of the formula R1 and (ii) a pharmaceutically acceptable liquid carrier compatible with the polyorthoester selected from polyethylene glycol ether derivatives having a molecular weight of between 200 and 4000, polyethylene glycol copolymers having a molecular weight of between 400 and 4000, mono-, di- or triglycerides of a C2-19 aliphatic carboxylic acid or a mixture of such acids, alkoxylated tetrahydrofurfuryl alcohols and their ethers and esters C1-4alkyl aliphatic C2-19 carboxylic acids and biocompatible oils and (B) granisetronUna composición farmacéutica que comprende: (A) un vehículo de administración semisólido, que comprende: (i) un poliortoéster de fórmula I o de fórmula II**Fórmula** donde: R es un enlace, -(CH2)a- o -(CH2)b-O-(CH2)c- en la que a es un número entero entre 1 y 10, y b y c son independientemente números enteros entre 1 y 5 R* es un alquilo C1-4 n es un número entero de al menos 5 y
