Pyrrolo sulfonamide compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-γ (ROR-γ, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases
Olaf Kinzel;Gerald Kleymann;Thomas Hoffmann;Christian Gege;Christoph Steeneck
发明人:
Christoph Steeneck,Olaf Kinzel,Christian Gege,Gerald Kleymann,Thomas Hoffmann
申请号：
US14110702
公开号：
US08946446B2
申请日:
2012.04.13
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administrating these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo sulfonamide compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.
