Novel compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (RORgamma, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune disease
Olaf Kinzel;Thomas Hoffman;Thomas Schlüter;Christoph Steeneck;Gerald Klaymann;Claus Kremoser;Michael Albers;Sanja Perovic-Ottstadt
发明人:
Olaf Kinzel,Christoph Steeneck,Gerald Klaymann,Michael Albers,Thomas Hoffman,Claus Kremoser,Sanja Perovic-Ottstadt,Thomas Schlüter
申请号：
US13581961
公开号：
US20130053380A1
申请日:
2011.02.28
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention provides modulators for the orphan nuclear receptor RORγ and methods for treating RORγ mediated diseases by administrating these novel RORγ modulators to a human or a mammal in need thereof. Specifically, the present invention provides compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.
