JI, BIN,季斌,HIGUCHI, MAKOTO,樋口真人,SUHARA, TETSUYA,须原哲也,須原哲也,CHEN,CHUN-JEN,陈忠正,陳忠正,FUJIMOTO, OSUKE,藤本央介
申请号：
TW108101192
公开号：
TW201929909A
申请日:
2019.01.11
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
Provided are a radionuclide-labeled compound having both tau protein affinity and amyloid protein affinity； an imaging agent that contains the radionuclide-labeled compound and that is used for imaging tau proteins and/or amyloid proteins； and a radioactive medicine that contains the radionuclide-labeled compound and that is used for diagnostic imaging of diseases caused by the aggregation of tau proteins and/or amyloid proteins. Radionuclide-labeled compounds represented by general formula (1) or salts thereof. (In the formula, X represents a radioactive iodine atom, 18F or 11CH3； pyridine and oxazole are bound by a carbon atom； and pyridine is bound to imidazopyridine by a carbon atom).本發明提供一種同時具有tau蛋白親和性及澱粉樣蛋白親和性之放射性核種標識化合物；含有放射性核種標識化合物之用於tau蛋白及/或澱粉樣蛋白之圖像化的成像劑；含有放射性核種標識化合物之用於因tau蛋白及/或澱粉樣蛋白之凝聚而引起的疾病之圖像診斷的放射性醫藥。一種下述通式(1)所示之放射性核種標識化合物或其鹽。(式中，X表示放射性碘原子、18F或11CH3，吡啶與噁唑係以碳原子鍵結，吡啶係以碳原子與咪唑并吡啶鍵結)。
