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METHODS OF TREATING LIVER FIBROSIS BY ADMINISTERING 3-BROMOPYRUVATE
专利权人:
The Johns Hopkins University
发明人:
Shanmugasundaram Ganapathy-Kanniappan,Surojit Sur,Bert Vogelstein,Kenneth W. Kinzler,Jean-Francois Geschwind
申请号:
US15773898
公开号:
US20180325847A1
申请日:
2016.11.04
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Methods for treating or preventing liver fibrosis in a subject by administering to the subject a therapeutically effective amount of 3-bromopyruvate (3-BrPA) are provided. In addition, methods for promoting the reversal of an activated hepatic stellate cell (HSC) to an inactivated HSC by contacting the activated HSC with at least one 3-bromopyruvate (3-BrPA) molecule are also provided.
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