Helen Tracey Horsley,Richard John Mears,Judi Charlotte Neuss,James Thomas Reuberson
申请号：
US16060486
公开号：
US10450320B2
申请日:
2016.12.08
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A series of 1,2,6,7,9,9a-hexahydropyrazino[1,2-d][1,2,4]triazin-4-one derivatives, substituted in the 8-position by an optionally substituted fused bicyclic heteroaromatic group, and in the 3-position by a range of functional groups, being selective inhibitors of phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders； viral diseases and malaria； and organ and cell transplant rejection.
