NOUVEAUX COMPOSÉS 2, 1 L-DIAZA-[3,3](2,6)PYRIDINOPHANE ET LEUR APPLICATION COMME LIGANDS D'AGENTS DE CONTRASTE IRM À BASE DE D'IONS MÉTALLIQUES ESSENTIELS ET D'AGENTS DE CONTRASTE TEP À BASE DE 52MN
The one subject of the invention is the compounds of general formula (I), their isomers, their physiologically acceptable salts and/or Mn(II), Fe(II), Fe(III), Co(II) and Ni(II) complexes. The other subject of the invention is the application of the above compounds. The compounds of general formula (I): wherein -NRR1 group may refer to: a) -NRR1 with N atom in the ring means a ring of 4 to 7, that in certain cases may contain another heteroatom, and in specific cases the ring may be replaced with an aryl group (of 5 to 7 carbon atoms) substituted with -COOH, -OH, -OCH3, -NO2, -NH2, -NCS, -NHS- activated ester, aryl (of 5 to 7 carbon atoms), or nitro-, amino- or isothiocyanate group, or b) in the -NRR1 group R means a H atom, alkyl, aryl, nitroaryl, aminoaryl or isothiocyanate-aryl group (of 1 to 6 carbon atoms) and R4 is a H atom, alkyl (of 1 to 6 carbon atoms) or -(CH2)n-COOH group, whereas n=1 to 10 integer, or c) -NRR1 group is one of the following groups: (formula II) whereas R2 is a H atom, carboxyl- or alkyl-carbonyl group (of 1 to 4 carbon atoms)；(formula III) and R2 is a H atom or alkyl or aryl group (of 1 to 6 carbon atoms), and X means independently from one another H atom, -CH3, -COOH, -OH, -OCH3, alkoxy- (of 2 to 6 carbon atoms), -NO2, -NH2, -NCS, -NHS -activated ester, alkyl (of 2 to 12 carbon atoms) or aryl (of 5 to 7 carbon atoms) group, in certain cases the latter may be substituted with hydroxyl, hydroxyalkyl (of 1 to 6 carbon atoms), nitro, amino or isothiocyanate group.L'invention concerne les composés de formule générale (I), leurs isomères, leurs sels physiologiquement acceptables et/ou des complexes Mn(II), Fe(II), Fe(III), Co(II) et Ni(II). Un autre objet de l'invention est l'application de ces composés. Les composés sont représentés par la formule générale (I), dans laquelle un groupe -NRR1 peut désigner : a) -NRR1 avec des atomes N dans le cycle désigne un cycle de 4 à 7, qui dans certains cas peut contenir un autre hétéroatome, et dans des
