NOUVEAUX COMPOSÉS À BASE DE 3,6,9,15-TÉTRAAZA-BICYCLO [9.3.1]PENTADÉCA-1(14),11(15),12-TRIÈNE ET LEUR APPLICATION COMME LIGANDS D'AGENTS DE CONTRASTE POUR IRM À BASE D'IONS MÉTALLIQUES ET POUR TEP À BASE DE 52MN
The one subject of the invention is the compounds of general formula (I), their isomers, their physiologically acceptable salts and/or Mn(II), Fe(II), Fe(III), Co(II) and Ni(II) complexes. The other subject of the invention is the application of the above compounds. The compounds of general formula (I): wherein Ra refers to -OH group or -NR3R4 group and -NR3R4 group may refer to: a) -NR3R4 with N atom in the ring means a ring of 4 to 7, that in certain cases may contain another heteroatom, and in specific cases the ring may be replaced with an aryl group (of 5 to 7 carbon atoms) substituted with -COOH, -OH, -OCH3, -NO2, -NH2, -NCS, -NHS- activated ester, aryl (of 5 to 7 carbon atoms), or nitro-, amino- or isothiocyanate group, or b) in the -NR3R4 group R3 means a H atom, alkyl, aryl, nitroaryl, aminoaryl or isothiocyanate-aryl group (of 1 to 6 carbon atoms) and R4 is a H atom, alkyl (of 1 to 6 carbon atoms) or -(CH2)n-COOH group, whereas n=1 to 10 integer, or c) -NR3R4 group is one of the below groups: whereas R1 is a H atom, carboxyl or alkyl-carbonyl group (of 1 to 4 carbon atoms)； and Rb is a H atom or alkyl group (of 1 to 6 carbon atoms), and X means independently from one another H atom, -CH3, -COOH, -OH, -OCH3, alkoxy- (of 2 to 6 carbon atoms), -NO2, -NH2, -NCS, -NHS-activated ester, alkyl (of 2 to 12 carbon atoms) or aryl (of 5 to 7 carbon atoms) group, in certain cases the latter may be substituted with hydroxyl, hydroxyalkyl (of 1 to 6 carbon atoms), nitro, amino or isothiocyanate group； and Y means: -NH- or >；NCH2-Z group, whereas in the >；CH2-Z group Z refers to one selected group of the below: -C(O)NR3R4 group, in which -NR3R4 means as referred to above, whereas z= 0- 18 integer, whereas z=0-18 integer, whereas z=0-18 integer, whereas z=0-18 integer and H atom, alkyl (of 1 to 6 carbon atoms) or -(CH2)n-COOH group, whereas n=l to 10 integer, or, whereas z= 0-18 integer, whereas z=0-18 integer and R2a refers to H atom, -OCH3, or -CF3 group, whereas R2b
