GENESTE HERVÉ,TURNER SEAN,OCHSE MICHAEL,DRESCHER KARLA,BLACK LAWRENCE A,JANTOS KATJA
申请号：
IN3836/DELNP/2015
公开号：
IN2015DN03836A
申请日:
2015.05.06
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention relates to compounds of the formula I and their salts etc. which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders wherein Y and Yare adjacent atoms in Het which are independently selected from the group consisting of carbon and nitrogen k is 0 1 2 or 3 Het is a bivalent monocyclic 5 or 6 membered heteroaromatic radical having 1 2 or 3 heteroatoms or heteroatom moieties selected from O S N and N R as ring members or a bivalent fused bicyclic 8 9 or 10 membered heteroaromatic radical having 1 2 3 or 4 heteroatoms or heteroatom moieties selected from O S N and N R as ring members Het is inter alia monocyclic 5 or 6 membered hetaryl having 1 2 or 3 heteroatoms or heteroatom moieties selected from O S N and N R as ring members Cyc is inter alia optionally substituted monocyclic 5 or 6 membered hetaryl or optionally substituted fused 8 9 or 10 membered bicyclic hetaryl Ar is optionally substituted phenylene or optionally substituted bivalent 6 membered hetaryl R is attached to a carbon atom of Het and inter alia halogen C C alkyl C C alkenyl C C alkynyl C C alkoxy C C fluoroalkyl C C fluoroalkoxy C C cycloalkyl etc.
