SWINNEN, Dominique,MONTAGNE, Cyril,POMEL, Vincent,QUATTROPANI, Anna,MOLETTE, Jerome,GERBER, Patrick
申请号：
ES12798612
公开号：
ES2606839T3
申请日:
2012.11.30
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Compound of formula (I) ** Formula ** in which R1, R2, R3 are independently selected from each other from H, straight or branched C1-C6 alkyl, straight or branched C1-C6 alkoxy, Hal or hydroxyl； Ra, Rb are independently selected from each other from H, Hal, hydroxyl or A； Q indicates a 6-membered aromatic group or a 5-6 membered heteroaromatic group having 1 to 4 heteroatoms independently selected from N, O, and S. R4 indicates G, OG, SG, OCHF2, OCF2CHF2, NR5G, -COOG, or OCOG； R5 denotes H or a linear or branched alkyl having 1 to 6 carbon atoms. G denotes -CH3, -CF3, -CH2 -A, Het, Cyc, Ar, -CH2 -Het, -CH2 -Cyc, -CH2-Ar, Hal, hydroxyl； Hal indicates F, Cl, Br or I, preferably F, Cl or Br； A is a straight or branched carbon chain having 1 to 6 carbon atoms, in which the non-adjacent -CH2 groups of 1 to 3 can be replaced independently of each other by a group selected from O, NR5, S, SO , SO2, CO, and in which the hydrogen atoms from 1 to 5 can be replaced independently of each other by Het, Cyc, Ar or Hal； Het denotes a saturated, unsaturated or aromatic ring, which is monocyclic or bicyclic or bicyclic condensed and having 3 to 8 members and containing 1 to 4 heteroatoms independently selected from N, NR5, O, S, CO, SO or SO2 , which can be substituted with from 1 to 3 substituents independently selected from A, Hal, OH and Het1； Het1 indicates a 4-, 5-, or 6-membered carbocyclic ring in which 1 or 2 carbon atoms are replaced by oxygen atoms. Ar denotes a 6-membered carbocyclic aromatic ring or a condensed or uncondensed bicyclic aromatic ring, and optionally substituted by 1 to 3 substituents independently selected from A or Hal； Cyc denotes a saturated or unsaturated carbocyclic ring having from 3 to 8 carbon atoms and optionally substituted by 1 to 3 substituents independently selected from A or Hal； and / or pharmaceutically usable tautomers, salts, solvates, and stereoisomers thereof.Compuesto de fórmula (I)**Fórmula** en la que R1, R2, R3 se seleccionan indepe
