PROBLEM TO BE SOLVED: To provide a drug for safely improving lipid metabolism of a hyperlipidemia patient showing resistance against a cholesterol synthesis inhibitor.SOLUTION: The drug is a reducing agent for apolipoprotein E in blood for a hyperlipidemia patient having an initial total cholesterol value in blood equal to or higher than 200 mg/d 1 and having resistance against a cholesterol synthesis inhibitor, the agent includes diglyceride, vegetable sterols and a HMG-CoA reductase inhibitor as effective ingredients.COPYRIGHT: (C)2013,JPO&INPIT【課題】コレステロール合成阻害薬に抵抗性を示す高脂血症患者における脂質代謝を安全に改善する薬剤の提供。【解決手段】ジグリセリドと、植物性ステロール類と、HMG-CoA還元酵素阻害剤を有効成分とする、初期の血中総コレステロール値≧200mg/dlであり、かつコレステロール合成阻害薬抵抗性の高脂血症患者における血中アポリポ蛋白E低下剤。【選択図】なし
