The invention relates to a medicinal preparation which contains melatonin and at least one antihypertensive compound, a method for treating patients with resistance to antihypertensives in the absence of melatonin, a method for decreasing nocturnal blood pressure of patients with blood pressure allorhythmia in the presence or absence of antihypertensives, and a method for providing patients with at least one of the following effects of: improvement of emotion and daytime insomnia, delay of cortisol peak level of patients, and potential preventive protection against harmful effect of ischemia on heart, wherein melatonin is applied with an effective amount and in an effective manner.
