A kind of bottle pinch roller is provided, which is configured to be attached to the bottle for accommodating drug. The bottle pinch roller includes various features, to help to be uniformly controlled the bottle of various sizes in automatic confecting device system. These bottle pinch roller features may include bottle groove, which is used to receive the bottle of specific dimensions and the bottle is fixed in the bottle groove. These features can also include cylindrical central portion, the vertical stretch extended from the top of the cylindrical central portion, the gear extended from the cylindrical central portion and the containment member being arranged in the cylindrical central portion. The bottle pinch roller may include cylindrical projections, which is configured to be pressed against the sealing on the diaphragm of the bottle to be formed between the bottle pinch roller and the bottle. The containment member can be configured to receive the syringe needle of the dispenser system, which passes through the containment member to allow access into the bottle.
