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FORMULATION LIQUIDE D'UN CONJUGUÉ D'HORMONE DE CROISSANCE HUMAINE À ACTION PROLONGÉE
专利权人:
LTD.;HANMI SCIENCE CO.
发明人:
HONG, SUNG HEE,LEE, BYUNG SUN,IM, DAE SEONG,LEE, JAE MIN,BAE, SUNG MIN,KWON, SE CHANG
申请号:
EP11807064
公开号:
EP2593084A4
申请日:
2011.07.14
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
Disclosed is a liquid formulation of long-acting human growth hormone (hGH) conjugate, free of albumin, which can guarantee the stability of the long-acting hGH conjugate when stored over a long period of time, wherein the long-acting human growth hormone conjugate includes a human growth hormone linked to an immunoglobulin Fc region, and has a prolonged in vivo stability compared to the native form. The liquid formulation of hGH conjugate including a pH 5.0˜6.0 buffer, a sugar alcohol, a salt and a non-ionic surfactant is free of human serum albumin and other hazardous factors which are potentially contaminated with viruses, and can provide excellent storage stability customized for a long-acting hGH conjugate composed of an hGH polypeptide and an immunoglobulin Fc region which has higher molecular weight and in vivo durability, compared to the native.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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