Sei Kwang Hahn,Min Young Lee,Jeonga Yang,Ho Sang Jung
申请号：
US14401922
公开号：
US20150150994A1
申请日:
2013.05.21
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to liver targeted drug delivery system using metal nanoparticles and a method for preparing the same. More particularly, the present invention relates to a method for preparing hyaluronic acid-gold nanoparticles/protein complex that can be used as liver targeted drug delivery system, by surface modifying gold nanoparticles having excellent stability in the body with hyaluronic acid having biocompatibility, biodegradability and liver tissue-specific delivery property, and binding protein drugs for treating liver diseases to the non-modified surface of the gold nanoparticles. And, the present invention relates to use of the hyaluronic acid-gold nanoparticles/protein complex for liver disease drug that may be safely applied to human body, increase drug efficacy duration time, and be effectively delivered to liver.
