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Anti-CDH3 humanized antibody, drug conjugate thereof, and use thereof
专利权人:
Perseus Proteomics Inc.
发明人:
Ishii, Keisuke,Mitomo, Katsuyuki,Kouda, Katsushi,Nomura, Fumiko,Kayukawa, Yoko,Matsuura, Tadashi
申请号:
AU2014216959
公开号:
AU2014216959A1
申请日:
2014.02.14
申请国别(地区):
AU
年份:
2015
代理人:
摘要:
The present invention addresses the problem of producing an anti-CDH3 humanized antibody having lower immunogenicity and provide an anti-CDH3 humanized antibody-drug conjugate using the same, said anti-CDH3 humanized antibody-drug conjugate being capable of more efficiently killing CDH3-expressing cancer cells. Provided is an anti-CDH3 humanized antibody-drug conjugate produced by linking an anti-CDH3 humanized antibody to a cytotoxic drug, wherein: the anti-CDH3 humanized antibody comprises complementarity determining region sequences originated from the heavy chain variable region of an antibody that is produced by a cell (Deposition No. NITE BP-1536) and complementarity determining region sequences originated from the light chain variable region thereof; the framework region sequences in the heavy chain variable region comprise a heavy chain human subgroup III consensus framework sequence or a human germ line sequence selected at the optimum alignment; and the framework region sequences in the light chain variable region include a light chain human κ subgroup I consensus framework sequence or a human germ line sequence selected at the optimum alignment.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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