DAVIS SAMUEL,MURPHY ANDREW J,STEVENS SEAN,BUCKLER DAVID R,MACDONALD LYNN,MCWHIRTER JOHN
申请号：
NZ61951211
公开号：
NZ619512A
申请日:
2011.02.08
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Patent No. 619512 Disclosed is a mouse that expresses a population of antigen-specific antibodies in response to challenge with an antigen, wherein all immunoglobulin light chains of the population of antigen-specific antibodies comprise a human immunoglobulin light chain variable (VL) region derived from a single rearranged human light chain variable region sequence in a germline of the mouse, wherein the single rearranged human light chain variable region sequence comprises a human germline V1-39 gene segment, wherein at least one of the population of antigen-specific antibodies comprises a light chain that is somatically mutated, and wherein the population of antigen-specific antibodies comprises a plurality of affinity-matured immunoglobulin heavy chains selected by the mouse, wherein each of the plurality of affinity matured heavy chains comprises a human immunoglobulin heavy chain variable (VH) region that pairs with said VL region, wherein the VH region comprises a sequence derived from one of a plurality of human VH segments including at least VH2-5, VH3-23, VH3-30, VH4-59, and VH5-51.
