CADILLA, RODOLFO,LARKIN, ANDREW,MCDOUGALD, DARRYL LYNN,RANDHAWA, AMARJIT SAB,RAY, JOHN A.,STETSON, KATHERINE,STEWART, EUGENE L.,TURNBULL, PHILIP STEWART,ZHOU, HUIQIANG
申请号：
ES07842385
公开号：
ES2452343T3
申请日:
2007.09.13
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula (I) ** Formula ** or a salt thereof, in which X and Y are each independently C or N； X and Y are not both N； R1 is H, OH, CN, halogen, C1-6 alkoxy or nitro； R2 is H, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, halogen or CN； R3 is H, halogen, C1-6 alkyl, C2-6 alkenyl, C1-6 haloalkyl, -C (O) R6, -CH2OH or (CH2) qRx； Rx is -C3-6cycloalkyl, -C (O) OCH3, -C (O) OR7 or -CN； q is 0, 1, 2, or 3； R4 is (R8) (R9)； R5 is H, C1-6 alkyl or halogen； R6 is H, C1-6 alkyl or NH2； R7 is C1-6 alkyl； R8 is C1-2 alkylene； R9 is oxadiazolyl, wherein said oxadiazolyl is optionally substituted with one or more substituents independently selected from Ra and Rb； Ra is CN, -C (O) R6, -NR12R13, C1-6 alkyl, C3-6 cycloalkyl, C1-3 haloalkyl, halogen or heterocyclyl, wherein said heterocyclyl is optionally substituted with one or more substituents independently selected from halogen, CN, C1-6 alkyl, C1-3 haloalkyl, -SCH3 and -S (O) 2CH3； Rb is phenyl optionally substituted with one or more substituents independently selected from -OH, halogen, C1-6 alkyl, C1-3 haloalkyl, C1-3 haloalkoxy, CN, nitro, C1-3 alkoxy, C3-6 cycloalkyl, heterocyclyl, - C (O) OCH3, -SCH3, -C (O) OH, -C (O) NR12R13, -S (O) 2CH3 and -C (O) CH3； R10 is -O-C1-6 alkyl, -NH2, -NHCH2CH3 or -N (CH3) 2； R12 and R13 are each independently selected from H and C1-6 alkyl； m is 0 or 1； p is 0 or 1； when Y is N, m is 0； and when X is N, p is 0.Un compuesto de fórmula (I) **Fórmula** o una sal del mismo, en la que X e Y son cada uno independientemente C o N； X e Y no son ambos N； R1 es H, OH, CN, halógeno, alcoxi C1-6 o nitro； R2 es H, alquilo C1-6, alcoxi C1-6, haloalquilo C1-6, halógeno o CN； R3 es H, halógeno, alquilo C1-6, alquenilo C2-6, haloalquilo C1-6, -C(O)R6, -CH2OH o (CH2)qRx； Rx es -cicloalquilo C3-6, -C(O)OCH3, -C(O)OR7 o -CN； q es 0, 1, 2, o 3； R4 es (R8)(R9)； R5 es H, alquilo C1-6 o halógeno； R6 es H, alquilo C1-6 o NH2； R7 es alquilo C1-6； R8 es alquileno C1-2； R9 es oxadiazolilo, en donde dicho oxadia
